/* RPL3L Initiative — modern theme */
:root {
  --ink: #0b0d12;
  --paper: #f7f7f4;
  --paper-alt: #eceae3;
  --card: #ffffff;
  --yellow: #e9ed4c;
  --orange: #ff9400;
  --green: #75a025;
  --pink: #fd9bed;
  --blue: #0279ee;
  --muted: #5c5f6a;
  --line: #e6e4dc;
  --radius: 16px;
  --shadow-sm: 0 1px 2px rgba(11, 13, 18, 0.05), 0 2px 8px rgba(11, 13, 18, 0.05);
  --shadow-md: 0 4px 12px rgba(11, 13, 18, 0.07), 0 12px 32px rgba(11, 13, 18, 0.09);
  --maxw: 1100px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
::selection { background: var(--yellow); color: var(--ink); }
:focus-visible { outline: 3px solid var(--blue); outline-offset: 2px; border-radius: 4px; }

body {
  margin: 0;
  font-family: "Inter", "Liberation Sans", Arimo, -apple-system, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
  background: var(--paper);
  color: var(--ink);
  line-height: 1.65;
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
}

/* ---------- Header / nav ---------- */
header.site {
  background: rgba(11, 13, 18, 0.82);
  color: var(--paper);
  position: sticky;
  top: 0;
  z-index: 50;
  backdrop-filter: blur(14px) saturate(1.4);
  -webkit-backdrop-filter: blur(14px) saturate(1.4);
  border-bottom: 1px solid rgba(255, 255, 255, 0.08);
}
.navwrap {
  max-width: var(--maxw);
  margin: 0 auto;
  padding: 0 1.5rem;
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 0.25rem 1rem;
}
.brand {
  display: flex;
  align-items: center;
  gap: 0.7rem;
  padding: 0.7rem 0;
  text-decoration: none;
  color: var(--paper);
}
.brand .mark {
  width: 38px; height: 38px;
  flex: none;
  filter: drop-shadow(0 2px 6px rgba(253, 155, 237, 0.35));
  transition: transform 0.25s ease;
}
.brand:hover .mark { transform: scale(1.06) rotate(-3deg); }
.brand .name { font-weight: 700; letter-spacing: -0.01em; font-size: 1.02rem; }
.brand .name small { display: block; font-weight: 400; font-size: 0.72rem; opacity: 0.65; letter-spacing: 0.01em; }
nav.main ul {
  list-style: none;
  display: flex;
  gap: 0.15rem;
  margin: 0; padding: 0;
  flex-wrap: wrap;
}
nav.main a {
  display: block;
  padding: 0.55rem 0.85rem;
  color: rgba(250, 249, 243, 0.85);
  text-decoration: none;
  font-size: 0.9rem;
  font-weight: 500;
  border-radius: 999px;
  transition: color 0.15s ease, background 0.15s ease;
}
nav.main a:hover { color: #fff; background: rgba(255, 255, 255, 0.1); }
nav.main a.active {
  background: linear-gradient(135deg, var(--blue), #4fb3e8);
  color: #fff;
  box-shadow: 0 2px 10px rgba(2, 121, 238, 0.4);
}

/* ---------- Hero ---------- */
.hero {
  position: relative;
  background: var(--ink);
  color: var(--paper);
  padding: 5.5rem 1.5rem 6rem;
  overflow: hidden;
}
.hero::before {
  content: "";
  position: absolute;
  inset: 0;
  background:
    radial-gradient(42rem 24rem at 12% -10%, rgba(2, 121, 238, 0.28), transparent 60%),
    radial-gradient(38rem 22rem at 88% 0%, rgba(253, 155, 237, 0.22), transparent 60%),
    radial-gradient(30rem 20rem at 55% 115%, rgba(255, 148, 0, 0.14), transparent 65%);
  pointer-events: none;
}
.hero .inner { position: relative; max-width: var(--maxw); margin: 0 auto; }
.hero h1 {
  font-size: clamp(2rem, 4.8vw, 3.2rem);
  margin: 0 0 1rem;
  line-height: 1.12;
  letter-spacing: -0.025em;
  font-weight: 800;
}
.hero h1 .line { display: block; }
.hero h1 .accent {
  background: linear-gradient(90deg, var(--yellow), var(--orange) 55%, var(--pink));
  -webkit-background-clip: text;
  background-clip: text;
  color: transparent;
}
.hero p.lede { font-size: 1.15rem; max-width: 46rem; opacity: 0.88; margin: 0 0 2rem; }
.btnrow { display: flex; gap: 0.8rem; flex-wrap: wrap; }
.btn {
  display: inline-block;
  padding: 0.75rem 1.5rem;
  border-radius: 999px;
  text-decoration: none;
  font-weight: 600;
  font-size: 0.95rem;
  border: 2px solid transparent;
  transition: transform 0.15s ease, box-shadow 0.15s ease, background 0.15s ease;
}
.btn:hover { transform: translateY(-2px); }
.btn.primary {
  background: linear-gradient(135deg, var(--yellow), var(--orange));
  color: var(--ink);
  box-shadow: 0 4px 16px rgba(255, 148, 0, 0.35);
}
.btn.primary:hover { box-shadow: 0 6px 22px rgba(255, 148, 0, 0.45); }
.btn.ghost { border-color: rgba(250, 249, 243, 0.4); color: var(--paper); }
.btn.ghost:hover { background: rgba(255, 255, 255, 0.1); border-color: rgba(250, 249, 243, 0.7); }

/* ---------- Layout ---------- */
main { max-width: var(--maxw); margin: 0 auto; padding: 3rem 1.5rem 3.5rem; }
section { margin-bottom: 3.5rem; scroll-margin-top: 5rem; }
h2 {
  font-size: 1.75rem;
  letter-spacing: -0.02em;
  margin: 0 0 0.75rem;
  display: inline-block;
  position: relative;
  padding-bottom: 0.4rem;
}
h2::after {
  content: "";
  position: absolute;
  left: 0; bottom: 0;
  width: 3.2rem; height: 4px;
  border-radius: 4px;
  background: linear-gradient(90deg, var(--yellow), var(--orange));
}
h3 { font-size: 1.15rem; margin: 1.6rem 0 0.4rem; letter-spacing: -0.01em; }
p { margin: 0.65rem 0; }
a { color: var(--blue); }
code {
  background: var(--paper-alt);
  padding: 0.12em 0.4em;
  border-radius: 6px;
  font-size: 0.88em;
  font-family: "SF Mono", ui-monospace, "Cascadia Code", Consolas, monospace;
}

/* ---------- Cards ---------- */
.cards {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(230px, 1fr));
  gap: 1.1rem;
}
.card {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 1.4rem 1.3rem;
  text-decoration: none;
  color: var(--ink);
  display: block;
  position: relative;
  box-shadow: var(--shadow-sm);
  transition: transform 0.18s ease, box-shadow 0.18s ease, border-color 0.18s ease;
  overflow: hidden;
}
.card::before {
  content: "";
  position: absolute;
  top: 0; left: 0; right: 0;
  height: 4px;
  background: var(--blue);
}
.card:hover { transform: translateY(-4px); box-shadow: var(--shadow-md); border-color: transparent; }
.card h3 { margin: 0.3rem 0 0.45rem; font-size: 1.05rem; }
.card p { font-size: 0.92rem; color: var(--muted); margin: 0; }
.card a { font-weight: 600; }
.card.c-yellow::before { background: linear-gradient(90deg, var(--yellow), var(--orange)); }
.card.c-orange::before { background: linear-gradient(90deg, var(--orange), var(--pink)); }
.card.c-green::before  { background: linear-gradient(90deg, var(--green), var(--yellow)); }
.card.c-pink::before   { background: linear-gradient(90deg, var(--pink), var(--blue)); }
.card.c-blue::before   { background: linear-gradient(90deg, var(--blue), var(--pink)); }

/* ---------- Fact strip ---------- */
.facts {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 1rem;
  background: linear-gradient(135deg, #14171f, #0b0d12);
  color: var(--paper);
  border-radius: var(--radius);
  padding: 1.8rem;
  box-shadow: var(--shadow-md);
  position: relative;
  overflow: hidden;
}
.facts::before {
  content: "";
  position: absolute;
  inset: 0;
  background: radial-gradient(24rem 12rem at 85% -20%, rgba(253, 155, 237, 0.18), transparent 60%);
  pointer-events: none;
}
.facts .fact { position: relative; }
.facts .fact b {
  display: block;
  font-size: 1.7rem;
  letter-spacing: -0.02em;
  background: linear-gradient(90deg, var(--yellow), var(--orange));
  -webkit-background-clip: text;
  background-clip: text;
  color: transparent;
}
.facts .fact span { font-size: 0.86rem; opacity: 0.75; }

/* ---------- Tables ---------- */
.table-scroll {
  overflow-x: auto;
  border-radius: var(--radius);
  box-shadow: var(--shadow-sm);
  border: 1px solid var(--line);
  background: var(--card);
}
table.data {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.9rem;
  background: transparent;
  border: none;
}
table.data th, table.data td {
  padding: 0.7rem 0.9rem;
  border-bottom: 1px solid var(--line);
  text-align: left;
  vertical-align: top;
}
table.data th {
  background: linear-gradient(135deg, #14171f, #23262f);
  color: var(--paper);
  font-weight: 600;
  font-size: 0.82rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  position: sticky;
  top: 0;
}
table.data td { background: var(--card); }
table.data tr:last-child td { border-bottom: none; }
table.data tbody tr { transition: background 0.12s ease; }
table.data tbody tr:hover td { background: #fbfaf6; }

/* ---------- Callouts ---------- */
.callout {
  border-left: 4px solid var(--orange);
  background: var(--card);
  padding: 1.1rem 1.4rem;
  border-radius: 0 var(--radius) var(--radius) 0;
  margin: 1.4rem 0;
  box-shadow: var(--shadow-sm);
}
.callout.blue { border-left-color: var(--blue); }
.callout.green { border-left-color: var(--green); }
.callout h3 { margin: 0 0 0.35rem; font-size: 1.02rem; }
.callout p { margin: 0.3rem 0; }

/* ---------- Timeline ---------- */
.timeline {
  list-style: none;
  margin: 1.25rem 0;
  padding: 0.4rem 0 0.4rem 1.6rem;
  border-left: 3px solid transparent;
  border-image: linear-gradient(180deg, var(--blue), var(--pink)) 1;
}
.timeline li { margin: 0 0 1.4rem; position: relative; }
.timeline li::before {
  content: "";
  position: absolute;
  left: -1.98rem;
  top: 0.42rem;
  width: 0.8rem; height: 0.8rem;
  border-radius: 50%;
  background: var(--blue);
  border: 3px solid var(--paper);
  box-shadow: 0 0 0 2px rgba(2, 121, 238, 0.35);
}
.timeline li.disease::before {
  background: var(--pink);
  box-shadow: 0 0 0 2px rgba(253, 155, 237, 0.45);
}
.timeline b.year {
  color: var(--ink);
  font-weight: 700;
  background: var(--paper-alt);
  padding: 0.08rem 0.55rem;
  border-radius: 999px;
  font-size: 0.88em;
}
.timeline-legend { font-size: 0.85rem; color: var(--muted); margin: 0.4rem 0 1rem; }
.timeline-legend .dot {
  display: inline-block;
  width: 0.68rem; height: 0.68rem;
  border-radius: 50%;
  margin: 0 0.32rem 0 0.9rem;
  vertical-align: baseline;
  box-shadow: 0 0 0 2px rgba(0, 0, 0, 0.06);
}
.timeline-legend .dot.gene { background: var(--blue); }
.timeline-legend .dot.dis { background: var(--pink); }

/* ---------- FAQ ---------- */
details {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 0.85rem 1.15rem;
  margin: 0.6rem 0;
  box-shadow: var(--shadow-sm);
  transition: box-shadow 0.15s ease;
}
details:hover { box-shadow: var(--shadow-md); }
details summary { font-weight: 600; cursor: pointer; }
details[open] summary { color: var(--blue); margin-bottom: 0.3rem; }

/* ---------- Footer ---------- */
footer.site {
  background: var(--ink);
  color: var(--paper);
  padding: 2.5rem 1.5rem 2rem;
  font-size: 0.88rem;
  position: relative;
  overflow: hidden;
}
footer.site::before {
  content: "";
  position: absolute;
  inset: 0;
  background: radial-gradient(30rem 14rem at 15% 120%, rgba(2, 121, 238, 0.16), transparent 60%);
  pointer-events: none;
}
footer.site .inner {
  position: relative;
  max-width: var(--maxw);
  margin: 0 auto;
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 1.5rem;
}
footer.site a { color: var(--yellow); text-decoration: none; }
footer.site a:hover { text-decoration: underline; }
.disclaimer {
  position: relative;
  max-width: var(--maxw);
  margin: 1.75rem auto 0;
  padding-top: 1.1rem;
  border-top: 1px solid rgba(255, 255, 255, 0.12);
  opacity: 0.6;
  font-size: 0.78rem;
  line-height: 1.55;
}

/* ---------- Misc ---------- */
.pill {
  display: inline-block;
  background: var(--paper-alt);
  border-radius: 999px;
  padding: 0.18rem 0.75rem;
  font-size: 0.8rem;
  font-weight: 600;
  margin: 0 0.3rem 0.3rem 0;
}
.pill.b { background: var(--blue); color: #fff; }
.pill.o { background: var(--orange); color: #fff; }
.pill.g { background: var(--green); color: #fff; }
.pill.p { background: var(--pink); }
.pill.y { background: var(--yellow); }
figure.heroimg { margin: 0; }
figure.heroimg img { width: 100%; border-radius: var(--radius); display: block; box-shadow: var(--shadow-md); }
figure.heroimg figcaption { font-size: 0.82rem; color: var(--muted); margin-top: 0.5rem; }
.reflist { font-size: 0.88rem; padding-left: 1.2rem; }
.reflist li { margin-bottom: 0.55rem; }

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition: none !important; }
}